FOXP2 and Human Cognition
نویسندگان
چکیده
منابع مشابه
FOXP2 and Human Cognition
Using a mouse model, Enard et al. (2009) show that the human form of the FOXP2 gene increases synaptic plasticity and dendrite connectivity in the basal ganglia. These results partly explain the enhanced capability of cortico-basal ganglia circuits in the human brain that regulate critical aspects of language, cognition, and motor control.
متن کاملFoxp2
The forkhead box P2 gene, designated FOXP2, is the first gene implicated in a speech and language disorder. Since its discovery, many studies have been carried out in an attempt to explain the mechanism by which it influences these characteristically human traits. This review presents the story of the discovery of the FOXP2 gene, including early studies of the phenotypic implications of a disru...
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Great apes cognitively represent and reason (make inferences) about the world. Humans, in addition, represent the world propositionally and conceptually (perspectivally), and they reason about it recursively and reflectively. The Shared Intentionality Hypothesis posits that these uniquely human forms of cognitive representation and reasoning emerged evolutionarily as cognitive adaptations for d...
متن کاملMonoallelic expression of the human FOXP2 speech gene.
The recent descriptions of widespread random monoallelic expression (RMAE) of genes distributed throughout the autosomal genome indicate that there are more genes subject to RMAE on autosomes than the number of genes on the X chromosome where X-inactivation dictates RMAE of X-linked genes. Several of the autosomal genes that undergo RMAE have independently been implicated in human Mendelian dis...
متن کاملThe Timing of Selection at the Human FOXP2 Gene
Krause J, Lalueza-Fox C, Orlando L, et al. recently examined patterns of genetic variation at FOXP2 in 2 Neanderthals. This gene is of particular interest because it is involved in speech and language and was previously shown to harbor the signature of recent positive selection. The authors found the same 2 amino acid substitutions in Neanderthals as in modern humans. Assuming that these sites ...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.05.013